Antiviral research : strategies in antiviral drug discovery by Robert L. LaFemina PDF

By Robert L. LaFemina

ISBN-10: 1555814395

ISBN-13: 9781555814397

ISBN-10: 1555815499

ISBN-13: 9781555815493

Captures the kingdom of the technological know-how with twenty reports that study the most recent in today’s antiviral drug discovery efforts.

  • Presents the basic rules of antiviral brokers and forecasts destiny possibilities.
  • Investigates novel enzyme and protein inhibitors.
  • Analyzes medical facets of viral an infection in regards to therapy and toxicity.
  • Examines recognized and power pursuits in any respect phases of viral improvement.
  • Serves as a source for virologists, biochemists, pharmaceutical chemists, and different investigators.
  • Covers a extensive variety of viruses, together with HIV-1, HSV, and HCV.

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P. Beardsley, and B. I. Schweitzer. 1997. Solution structure of a DNA decamer containing the antiviral drug ganciclovir: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement. Biochemistry 36:5336–5345. 55. Franklin, M. , J. Wang, and T. A. Steitz. 2001. Structure of the replicating complex of a pol a family DNA polymerase. Cell 105:657–667. 56. Freitas, V. , D. F. Smee, M. Chernow, R. Boehme, and T. R. Matthews. 1985. Activity of 9-(1,3-dihydroxy-2-propoxymethyl) guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses.

Kalmer, S. Auerochs, P. Lischka, M. Leis, and T. Stamminger. CHAPTER 1 • ANTIHERPESVIRAL DNA Pol INHIBITORS 17 2005. Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina. J. Biol. Chem. 280:33357–33367. 106. Martin, J. , C. A. Dvorack, D. E. Smee, T. R. Matthews, and J. P. H. Verheyden. 1983. 9-[(1,3-dihydroxy-2-propoxy) methyl]guanine: a new potent and selective antiherpesvirus agent. J. Med. Chem. 26:759–761. 107. Martin, J. , C. E. Brown, N. Matthews-Davis, and J.

1993. The mode of action of penciclovir. Antivir. Chem. Chemother. 4:13–24. 152. , L. Corey, R. Cone, A. Hobson, G. Davis, and J. Zeh. 1997. Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment. J. Clin. Investig. 99:1092–1097. 153. , A. K. Sattar, C. C. Wang, J. D. Karam, W. H. Konigsberg, and T. A. Steitz. 1997. Crystal structure of a pol a family replication DNA polymerase from bacteriophage RB69. Cell 89:1087–1099. 154. , G. Mahalingam, S.

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