By Eric T. Wong
This concise textual content offers an entire evaluate of alternating electrical fields treatment -- sometimes called tumor treating fields -- for glioblastoma and different varieties of good tumor malignancies. Readers are given a basic figuring out of this novel anti-cancer therapy modality by way of studying from scientific trial information in addition to the actual and telephone biology results on tumor cells whilst alternating electrical fields are utilized either in vitro and in vivo.
Chapters illustrate the physics in the back of electrical box propagation in house and different media. this can be through a assessment of our present knowing of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the telephone floor chaperons that set off immunogenic telephone dying. facts from part III trials for the therapy of recurrent and newly clinically determined glioblastomas are incorporated, in addition to the various ancillary post hoc analyses that have been played via quite a few investigators. the rest of the bankruptcy covers different good tumor malignancies, together with non-small cellphone lung melanoma, pancreatic melanoma and ovarian melanoma, as this therapy modality is being utilized to systemic malignancies.
Alternating electrical Fields remedy in Oncology deals oncologists, neurologists, radiation oncologists, biomedical engineers, telephone biologists and mitosis researchers the basics wanted for scientific practice.
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Extra info for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields
Derivatives of these equations to account for time-varying TTFields are essential to accurately describe the alternating electric field distribution within the brain during every cycle. Brain tissues are essentially dielectric materials with different conductivity and relative permittivity properties that change the electric field distribution due to their respective capacitive reactance characteristics and thus these distributions are nonuniform. Since TTFields are applied continuously in the patient, a more appropriate physical quantity to describe the amount of energy absorbed in the tissue media may be expressed in terms of power.
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Microbial growth inhibition by alternating electric fields. Antimicrob Agents Chemother. 2008;52(10):3517–22. 17. Stupp R, Wong ET, Kanner AA, Steinberg D, Engelhard H, Heidecke V, et al. NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: a randomised phase III trial of a novel treatment modality. Eur J Cancer. 2012;48(14):2192–202. 18. Stupp R, Taillibert S, Kanner AA, Kesari S, Steinberg DM, Toms SA, et al. Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: a randomized clinical trial.
Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields by Eric T. Wong
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