Download e-book for iPad: Alcohol And the Gastrointestinal Tract: Special Issue: by M. V. Singer, D. Brenner

By M. V. Singer, D. Brenner

ISBN-10: 3805580304

ISBN-13: 9783805580304

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Additional resources for Alcohol And the Gastrointestinal Tract: Special Issue: Digestive Diseases 2005

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In another investigation, an elevation in oxidative stress markers was found in pancreatic tissue. Since histological pancreatic damage was not observed, the elevation in oxidative stress markers was suggested to occur as a primary phenomenon rather than as part of an inflammatory response [76]. In a recent study with Lieber-DeCarli ethanol-fed rats, pancreatic gene expression was investigated using mRNA differential display [77]. Pancreatic cholesterol esterase mRNA levels were enhanced in the pancreas and liver, and similar patterns were found for other fatty acid ethyl ester-related genes suggesting that the pancreatic cholesterol esterase gene might play an important role in the development of alcohol-related pancreatic damage [77].

34 Hernandez-Munoz R, Montiel-Ruiz C, Vazquez-Martinez O: Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Lab Invest 2000; 80: 1161–1169. 35 Jedrzejewska A, Staff-Zielinska E: Neuropathology of intramural autonomic innervation of mice stomach in chronic ethanol intoxication. Zentralbl Allg Pathol 1990; 136: 571– 577. 36 Beck IT, Morris GP, Buell MG: Ethanol-induced vascular permeability changes in the jejunal mucosa of the dog.

They observed a significant increase in the size of the basal cell layer and basal cell nuclei of oral epithelium and an increase in the percentage of cells in the S-phase of the cell cycle. The mean epithelial thickness was reduced. They suggested that the chronic ethanol consumption caused oral mucosal atrophy with associated hyper-regeneration, which in turn may result in an enhanced susceptibility of the mucosal epithelium towards chemical carcinogens. The underlying mechanisms of the increased proliferative activity of the mucosal epithelium of the oral cavity are still unclear, but it is believed that this hyper-regeneration might be caused by a cytotoxic effect of ethanol.

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Alcohol And the Gastrointestinal Tract: Special Issue: Digestive Diseases 2005 by M. V. Singer, D. Brenner


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Download e-book for iPad: Alcohol And the Gastrointestinal Tract: Special Issue: by M. V. Singer, D. Brenner
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