By David T. Curiel
Adenoviral Vectors for Gene remedy, moment Edition offers specified, complete assurance of the gene supply automobiles which are in keeping with the adenovirus that's rising as a huge instrument in gene remedy. those fascinating new healing brokers have nice capability for the therapy of affliction, making gene treatment a fast-growing box for examine.
This e-book offers themes starting from the elemental biology of adenoviruses, during the building and purification of adenoviral vectors, state-of-the-art vectorology, and using adenoviral vectors in preclinical animal versions, with ultimate attention of the regulatory matters surrounding human scientific gene remedy trials. This wide scope of data presents an excellent review of the sphere, permitting the reader to achieve an entire realizing of the improvement and use of adenoviral vectors.
- Provides entire insurance of the fundamental biology of adenoviruses, in addition to their development, propagation, and purification of adenoviral vectors
- Introduces universal concepts for the improvement of adenoviral vectors, besides state of the art tools for his or her improvement
- Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
- Discusses software of adenoviral vectors in animal sickness models
- Considers Federal Drug management rules for human scientific trials
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Additional info for Adenoviral Vectors for Gene Therapy, Second Edition
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases. J Virol 1998; 72:8806–12. Albinsson B, Kidd AH. Adenovirus type 41 lacks an RGD α(v)-integrin binding motif on the penton base and undergoes delayed uptake in A549 cells. Virus Res 1999;64:125–36. Davison AJ, Telford EA, Watson MS, McBride K, Mautner V. The DNA sequence of adenovirus type 40. J Mol Biol 1993;234:1308–16. Stewart PL, Chiu CY, Huang S, Muir T, Zhao Y, Chait B, et al. Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization.
Ceramide lipids enhance virus endocytosis and interact with protein VI in endosomes, thereby enhancing endosomal lysis. This provides evidence for a positive feedback loop between limited virus uncoating, protein VI-mediated membrane lysis, and localized lipid production. 205,221 42 Adenoviral Vectors for Gene Therapy 6. Targeting the Nucleus HAdVs engage with cytoskeleton-dependent motor proteins to transit the cytoplasm from the site of endosomal escape to the nucleus. 1 Transport through the Cytoplasm Long-range cytoplasmic transport is largely mediated by microtubules (MT) and associated motors.
The other serotypes are grouped together if they have similar binding properties. D 31 32 Adenoviral Vectors for Gene Therapy or integrins, are scarce or constrained to the basolateral surface of polarized epithelia. Besides attachment, CAR, integrins, CD46, or DSG2 themselves have a crucial role in virus endocytosis, uncoating, and signaling. These aspects determine productive entry, gene expression, and infection. For most of the other factors proposed to mediate AdV attachment to cells, a specific role in infection has not been identified.
Adenoviral Vectors for Gene Therapy, Second Edition by David T. Curiel
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